MS Psilocybin law · Reviewed Nov 12, 2026
Psilocybin mushrooms remain illegal in Mississippi; psilocybin and psilocyn are Schedule I substances.
No separate first-offense rule is stated. For less than 0.1 gram or two dosage units, simple possession is a misdemeanor punishable by up to 1 year in jail, a $1,000 fine, or both; penalties increase with amount, and 30 grams or more is trafficking.
Mississippi has no psilocybin medical, therapy, or access program. SB 2056 provides automatic state scheduling for an FDA-approved crystalline-polymorph psilocybin drug once DEA-scheduled; it does not create a treatment program.
No city or county measures found in our sources.
The sources state that psilocybin spores may be sold for microscopy; growing them is illegal.
A source states that Amanita muscaria products are lawful to purchase.
HB 314 concerns ibogaine clinical-trial development, not psilocybin. The sources do not state a Mississippi MDMA- or LSD-related program.
Mississippi has a law that would let doctors prescribe an FDA-approved psilocybin medicine once federal approval and rescheduling happen. It does not legalize mushrooms.
March 11: HB 563, which also proposed automatic psilocybin scheduling, died on the Senate calendar.
March 13: SB 2056 was approved by the governor.
March 26: HB 314, an ibogaine clinical-trial act, was signed; it does not concern psilocybin.
July 1: SB 2056 took effect. Psilocybin mushrooms remained Schedule I; the law covers only qualifying FDA-approved pharmaceutical psilocybin after DEA scheduling.
July 1: The reprinted Schedule I listing took effect and continued to list psilocybin and psilocyn.
Number of states in each category. Mississippi’s category is highlighted.
Access score from 0 (illegal) to 5 (licensed adult access).
Listings describe themselves; Pscilly does not sell psilocybin, and sellers outside a state program are labeled “not state-licensed.”
Psilocybin mushrooms remain illegal in Mississippi; psilocybin and psilocyn are Schedule I substances.
No separate first-offense rule is stated. For less than 0.1 gram or two dosage units, simple possession is a misdemeanor punishable by up to 1 year in jail, a $1,000 fine, or both; penalties increase with amount, and 30 grams or more is trafficking.
Mississippi has no psilocybin medical, therapy, or access program. SB 2056 provides automatic state scheduling for an FDA-approved crystalline-polymorph psilocybin drug once DEA-scheduled; it does not create a treatment program.
The sources state that psilocybin spores may be sold for microscopy; growing them is illegal.
A source states that Amanita muscaria products are lawful to purchase.
Pscilly classifies Mississippi as: illegal. Laws change often, so check the linked sources and current state rules.
Educational summary, not legal advice. Pscilly reviewed these laws on November 12, 2026 using the sources listed; laws change often, so confirm current rules with the state or a lawyer. Psilocybin remains a Schedule I controlled substance under federal law.
Pscilly is a mushroom directory and marketplace for the U.S., Canada, Europe and beyond, covering mushroom shops, licensed psilocybin centers, smart shops, retreats, mushroom brands, delivery services, events and deals. Listings come from the businesses themselves and from public sources, and every listing links to the business.